• MtDNA is usually present in multiple identical copies in

  2018-10-23

  

  MtDNA is usually present in multiple identical copies in the cells, but the location of MtDNA close to the electron transport chain renders it more susceptible to ROS induced damage and mutations. In diabetes patients, MtDNA may be exposed to hyperglycaemia induced oxidative stress (Singh et al., 20

• br Discussion Our studies suggest that over expression of

  2018-10-23

  

  Discussion Our studies suggest that over-expression of both XIST and KDM5C genes may serve as a biological marker for diagnosis of bipolar disorder with mania and psychosis or recurrent major depression in females. In 60 lymphoblastoid cell lines established from randomly collected female patient

• The levels of LRG have been shown to be

  2018-10-23

  

  The levels of LRG1 have been shown to be elevated in the serum and urinary exosomes of lung cancer patients (Li et al., 2011; Liu et al., 2012) with this protein also being identified in lung tumour tissue. The role of LRG1 is not fully understood, although it is of interest due to its role in angio

• Compared to SFAs convincing evidence observed in our study

  2018-10-23

  

  Compared to SFAs, convincing evidence observed in our study was that UFAs are more closely associated with metabolic status in obese individuals. The fluctuations of circulating FFAs in obese phenotypes may be due to the different FA mobilization mechanisms from adipose tissue to blood, where SFAs w

• br Materials and Methods br

  2018-10-23

  

  Materials and Methods Results Discussion The relative frequency of myeloid and lymphoid AVE 0991 is increasingly recognised as a variable distinct from its constituents, but the pathophysiologic basis of association remains unclear. Our observation of monocyte functional and transcriptiona

• br Acknowledgments Funding for this

  2018-10-23

  

  Acknowledgments Funding for this study was obtained from the South African Medical Research Council for self-initiated research from November 2012 to April 2015 and the Lily and Ernst Hausmann Research Trust to Bongani Mayosi, and the National Institute of Allergy and Infectious Diseases of the N

• trp channels d Dimer may be the biomarker most strongly

  2018-10-23

  

  d-Dimer may be the biomarker most strongly associated with adverse events in HIV infection — from all-cause mortality in the SMART trial to venous thromboembolism and cardiovascular disease in prior published work (Kuller et al., 2008; Musselwhite et al., 2011; Nordell et al., 2014). Recent studies

• Previous work showed that lncRNAs

  2018-10-23

  

  Previous work showed that lncRNAs show higher tissue specificity compared to mRNAs (). The work of Ching et al. supported this notion, and extended it by showing a reduction of specificity after malignant transformation, which is consistent with the de-differentiation status of cancers widely observ

• Influenza proteins inside the viral envelope are highly

  2018-10-23

  

  Influenza proteins inside the viral envelope are highly conserved across different strains and subtypes of influenza. Two internal proteins that have been extensively studied in the context of influenza infection are nucleoprotein (NP) and matrix protein 1 (M1). NP binds and transports the RNA genom

• Existing evidence indicates that both long and short term me

  2018-10-23

  

  Existing evidence indicates that procyanidin b2 both long- and short-term meditation practices change individuals\' affective processing and regulatory patterns (Chiesa et al., 2013). Theoretically, meditation emphasizes non-judgmental, open observations of thoughts, feelings, and stimuli from a no

• br Funding Sources This work

  2018-10-23

  

  Funding Sources This work was supported by Cancer Research UK (C1094/A11728 to CMLW and NGB for the RAPPER study, C26900/A8740 to GCB, and C8197/A10865 to AMD), the Royal College of Radiologists (C26900/A8740 to GCB), the National Institute for Health Research (GCB; no grant number), Addenbrooke\

• Metabonomic alterations as a result

  2018-10-23

  

  Metabonomic alterations as a result of antibiotic use are important in the context of CDI (Theriot et al., 2014). As an example, primary and secondary bile acids have markedly different effects on C. difficile; primary bile acids promote growth of this pathogen while secondary bile acids are inhibit

• Collagen I and various proteoglycans contribute

  2018-10-23

  

  Collagen I and various proteoglycans contribute to the tensile strength and viscoelastic properties of the tendon tissue, respectively (Puxkandl et al., 2002; Robinson et al., 2004). Furthermore, proteoglycans and cross-linking ionophores modulate collagen I fibrillogenesis during rest and training

• The shape of the observed PK concentration time profile foll

  2018-10-23

  

  The shape of the observed PK concentration-time profile following IH administration was consistent with the IM PK profile (Fig. 3). Plasma oxytocin was detectable in all subjects at the first sampling time (3min post-dose) and remained quantifiable in 5/16 subjects up to 4h following IM administrati

• histamine receptors The results of the direct quasistatic ca

  2018-10-23

  

  The results of the direct, quasistatic calculations of the bulk value of the Young׳s modulus in step (2) are summarized in Table 2. k-points for the tetragonal and orthorhombic unit histamine receptors were also chosen according to the Monkhorst–Pack scheme. In Table 2 the number of divisions n, h

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