FUS binds to DNA as well as to RNA

2018-10-20

FUS binds to DNA as well as to RNA and regulates the expression of many transcripts in multiple steps of the gene regulation process (Dormann and Haass, 2013). In this study, we used FALS MPCs efficiently oriented into neuronal lineages including HB9-positive motor neurons to observe altered gene re

To address whether the bivalent state requires

2018-10-20

To address whether the bivalent state requires miRNAs or other Dicer-dependent functions, we reconstituted Dicer-deficient ESCs with miR-294, a member of the miR-290–295 miRNA family. ChIP-PCR showed that EZH2 binding was restored 48 hr later at the Gata3, Pax6, and Nr2f2 promoters (Figure 4B). Thus

Given that the ECM becomes more

2018-10-20

Given that the ECM becomes more complex as ECs differentiate, it is of particular interest to understand the outside-in signaling that might modulate their behavior. Similar to other cell types, ECs interact with their environment in large part via the integrin family of adhesion receptors that cons

br Experimental Procedure br Author Contributions br Introdu

2018-10-20

Experimental Procedure Author Contributions Introduction The human heart develops as the first functional organ in the embryo. In the lateral plate mesoderm (LPM) cardiac progenitor endothelin receptor antagonists are induced, which can subsequently differentiate into heart muscle cells (c

G lucidum is a medicinal mushroom well known for

2018-10-20

G. lucidum is a medicinal mushroom well known for its legendary anti-aging benefits. Our findings that GLP not only promote NPC proliferation but also reduce amyloid deposits provide potential underlying mechanisms of its anti-aging effects. Extract of G. lucidum has also been reported to inhibit th

Hello world!

2018-07-29