• The negative long term effects of

  2018-10-20

  

  The negative, long term effects of alcoholism on bone mass have been well-established (Feskanich et al., 1999). Studies have shown that heavy chronic alcohol consumption compromises bone quality and increases the risk for osteoporosis. Other studies have shown that alcoholism is associated with a va

• The TSD patient fibroblasts were reprogrammed using the STEM

  2018-10-20

  

  The TSD patient fibroblasts were reprogrammed using the STEMCCA lentivirus, which express OCT4, SOX2, KLF4, and c-MYC (OSKM) from a polycistronic transcript (Somers et al. 2010). TSD-01-hiPSC form colonies typical to human pluripotent stem p38 mapk inhibitor and express pluripotency markers such as

• In our previous studies we successfully

  2018-10-20

  

  In our previous studies, we successfully synthesized poly(hydroxyethyl methacrylate) (pHEMA) derived-polymers differing in the amount of 2-methacryloyloxyethyltrimethyl ammonium chloride (METAC) (Rosso et al., 2003; De Rosa et al., 2004). We demonstrated that positively charged moieties on the polym

• Our data indicate that common oncogenic mutations

  2018-10-20

  

  Our data indicate that common oncogenic mutations sequentially induce the loss of the immunomodulatory capacity of hBMSCs by preventing the production of immunoregulatory prostacyclins and inducing a proinflammatory profile. This implies an important functional consequence. It is recognized that tis

• The results presented here sug http www surface antigen

  2018-10-20

  

  The results presented here suggest that HIF and MYC are antagonistic to each other in neurogenesis. While others have suggested that this could be the case in other types of Dihydromyricetin (Koshiji et al., 2004; Yoon et al., 2010), the mechanism proposed here is distinct. We found that a portion

• Taken together we here show

  2018-10-20

  

  Taken together, we here show that the recently identified marker SPOT14 labels low-proliferating NSPCs in the hippocampus that react dynamically to positive and negative neurogenic stimuli in vivo. These data further validate the usefulness of this restrictive and functionally relevant marker to ana

• We demonstrated that CFTR gene correction

  2018-10-20

  

  We demonstrated that CFTR gene correction resulted in restoration of expression of the mature CFTR glycoprotein and CFTR chloride channel function in iPSC-derived epithelial cells. Mutant clone 17 monolayers, when treated with CFTR corrector VX809, exhibited partial restoration of CFTR-mediated chlo

• Tozadenant br Results br Discussion In the two dry AMD patie

  2018-10-20

  

  Results Discussion In the two dry AMD patients and one SMD patient, increasing subretinal pigmentation developed at the hESC-RPE cell injection site as has been noted previously (Schwartz et al., 2012, 2015). In the second dry AMD patient and the second SMD patient, multiple spots of increased

• Here we present an algorithm KeyGenes that we

  2018-10-20

  

  Here we present an algorithm, KeyGenes, that we have used on NGS data extracted from tissues of 21 different human fetal organs, both embryonic and extraembryonic (plus the maternal endometrium), from the first and second trimesters of development to determine a panel of classifier genes that would

• br Experimental Procedures br Acknowledgments br Introductio

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction The human palatine tonsil is part of a circular collection of specialized B-lymphoid structures located in the oropharynx at the opening of the aerodigestive tract (Figure 1A). The outer surface of the human palatine tonsil is lined with

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments We thank Y. Sasai (RIKEN, Japan) for the RAX-GFP mESC line, M. Wegner (University of Erlangen, Germany) for SOX9, E. Tanaka (CRTD, Germany) for RAX and CRX, and D. Forrest (NIDDK, USA) for TRβ2 antibodies. We thank J. Brzezinski (

• FUS binds to DNA as well as to RNA

  2018-10-20

  

  FUS binds to DNA as well as to RNA and regulates the expression of many transcripts in multiple steps of the gene regulation process (Dormann and Haass, 2013). In this study, we used FALS MPCs efficiently oriented into neuronal lineages including HB9-positive motor neurons to observe altered gene re

• To address whether the bivalent state requires

  2018-10-20

  

  To address whether the bivalent state requires miRNAs or other Dicer-dependent functions, we reconstituted Dicer-deficient ESCs with miR-294, a member of the miR-290–295 miRNA family. ChIP-PCR showed that EZH2 binding was restored 48 hr later at the Gata3, Pax6, and Nr2f2 promoters (Figure 4B). Thus

• Given that the ECM becomes more

  2018-10-20

  

  Given that the ECM becomes more complex as ECs differentiate, it is of particular interest to understand the outside-in signaling that might modulate their behavior. Similar to other cell types, ECs interact with their environment in large part via the integrin family of adhesion receptors that cons

• br Experimental Procedure br Author Contributions br Introdu

  2018-10-20

  

  Experimental Procedure Author Contributions Introduction The human heart develops as the first functional organ in the embryo. In the lateral plate mesoderm (LPM) cardiac progenitor endothelin receptor antagonists are induced, which can subsequently differentiate into heart muscle cells (c

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