• bms-690514 The next goal for gene therapy is the directed in

  2018-11-08

  

  The next goal for gene therapy is the directed insertion of the therapeutic sequences in the cell genome (Garate et al., 2013; Genovese et al., 2014; Karakikes et al., 2015; Song et al., 2015). A number of different gene-editing strategies have been described, including gene modification of the spe

• br Experimental Procedures Extended experimental

  2018-11-08

  

  Experimental Procedures Extended experimental procedures are provided in the Supplemental Information. Author Contributions Acknowledgments This work was supported by grants from Breakthrough Breast Cancer, the Swedish Cancer Foundation, the Swedish Research Council, Sahlgrenska Academy (A

• THZ531 br Conflict of interest br Acknowledgements

  2018-11-07

  

  Conflict of interest Acknowledgements The HBSC is a WHO/Euro collaborative study; International Coordinator of the 2014 study was Candace Currie, St. Andrews University, Scotland; Data Bank Manager is Oddrun Samdal, University of Bergen, Norway. The 6 countries involved in this analysis (curre

• As above mentioned in both countries the

  2018-11-07

  

  As above-mentioned in both countries (the Netherlands and the Philippines), pride is an important driver of both sales performance and citizenship behaviors. Therefore it is important for managers to instill pride in their salesforce as it has broaden-and-build effects on other emotions (Fredrickson

• GSK2656157 It has however to be taken into account that in

  2018-11-07

  

  It has, however, to be taken into account that in the present study the measure of sleep duration was exclusively subjective. It is known that sleep time misperceptions are common among subjects with sleep difficulties, particularly insomnia, with a however broad continuum between substantial under-

• Como se desprende de la gr fica

  2018-11-07

  

  Como se desprende de la gráfica 3, el esfuerzo de ajuste fiscal a partir de 2016 deberá ser muy grande, ya que un año después de la reforma energética de 2008, basada en leyes secundarias, que incluyó el relajamiento de la Ley Federal de Presupuesto y Responsabilidad Hacendaria en materia de manteni

• In practical terms as described in Becker and Ichino

  2018-11-07

  

  In practical terms, as described in Becker and Ichino (2002) or Khandker et al. (2010), to sustain these two hypotheses, one chooses a sub-sample following the protocol of matching the treatment and control groups (leaving the sub-sample components sufficiently similar in terms of covariates). In th

• However Ae albopictus was responsible for

  2018-11-07

  

  However, Ae. albopictus was responsible for the epidemic transmission of chikungunya, an alphavirus, in Italy 2007 (Carrieri et al., 2011). Therefore, it is unlikely that at that time factor 1) - insufficient Ae. albopictus population - is the main reason for not having dengue outbreaks in Europe, u

• The clinical heterogeneity in AOS patients

  2018-11-07

  

  The clinical heterogeneity in AOS patients makes it difficult to study SMAD3 mutational effects on aneurysm formation. Fortunately, due to the homogenous genetic background, genetically engineered mouse models are useful in pinpointing the specific molecular mechanism leading to disease. Smad3 knock

• Tenofovir alafenamide TAF National Center for

  2018-11-07

  

  Tenofovir alafenamide (TAF) (National Center for Biotechnology Information, n.d.-b, CID=9,574,768) is a prodrug of TFV that is more stable in plasma, allowing for a ten-fold reduction in dose and resulting in a 91% reduction in BIS-TRIS TFV while achieving a four-fold increase in intracellular leve

• Overall obesity can lead to renal functional

  2018-11-07

  

  Overall, obesity can lead to renal functional disorders and induce hypertension through a variety of mechanisms: (Hall, 1997; Hall et al., 1999; Hall et al., 2002; Hall et al., 2010; Hall et al., 2015; Hall et al., 2014). Activation of sympathetic nervous system; Physical–mechanical compression; Ren

• SR 3576 We first confirmed PDLIM overexpression in primary

  2018-11-07

  

  We first confirmed PDLIM2 overexpression in primary meningioma and schwannoma samples and showed that it is not expressed in HMC or normal meningeal tissue and minimally expressed in the Schwann cell examined. PDLIM2 was significantly knocked down in three primary meningioma and three primary schwan

• br Specifications table br Value

  2018-11-07

  

  Specifications table Value of the data Data, experimental design, materials and methods C57BL/6 mice (sacrificed after 1, 3, 7, 10 and 14 days post-natal, n=3/age) were obtained from a colony at the Max Planck Institute for Molecular Genetics (Berlin, Germany) and left femora were dissected

• Workflow Mascot Distiller Mascot Skyline MS Signal analysis

  2018-11-07

  

  Workflow 8: Mascot Distiller/Mascot/Skyline/MS Signal analysis. Peaklist creation was performed with Mascot Distiller as described in workflow 3, then database searches were performed with Mascot and validated with Scaffold as described for workflow 4. XIC signal corresponding to all validated pepti

• br Experimental design materials and

  2018-11-07

  

  Experimental design, materials and methods Conflict of Interest The authors (KMK, JRR, MAB, KMR) of this UO 126 manuscript (Functional magnetic resonance imaging data of incremental increases in visuo-spatial difficulty in an adult lifespan sample) have no conflicts of interest to report.

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