• br Results To develop iPSC

  2018-10-24

  

  Results To develop iPSC-based model systems of disease, we first prepared a bank of >60 iPSC clones (ten clones per donor; partial set and reprogramming methodology described previously [Mills et al., 2013; Somers et al., 2010]) derived from the dermal fibroblasts of three control individuals wit

• br Experimental Procedures Full details are

  2018-10-24

  

  Experimental Procedures Full details are given in the Supplemental Experimental Procedures. Author Contributions Acknowledgments We are grateful to Marcos Araúzo-Bravo (BioDonostia Health Research Institute, Spain) for his helpful advice on microarray data analysis. We thank Michele Boiani

• br Introduction Cardiac and skeletal myogenesis both generat

  2018-10-24

  

  Introduction Cardiac and skeletal myogenesis both generate striated muscle, but are traditionally thought of as two separate processes with distinct developmental anlagen. However, recent work suggests the existence of at least one bipotent anlage for cardiac and skeletal muscle: the common proge

• Taken together these findings indicate that

  2018-10-24

  

  Taken together, these findings indicate that basal-to-luminal differentiation can occur in prostate organogenesis, pathogenesis, and ex vivo assays, but rarely during normal tissue homeostasis. Thus, it has been unclear to what extent the plasticity of endogenous adult prostate basal monensin Suppli

• Multiple factors through binding to GPCRs

  2018-10-24

  

  Multiple factors, through binding to GPCRs, orchestrate the regulation of cAMP levels in a cell- and context-dependent manner, an effect that is most likely to be preserved during embryonic hematopoietic emergence and development (Diaz et al., 2015; Goessling et al., 2011; Hoggatt et al., 2009; Jing

• purchase EPZ015666 br Results br Discussion Muscle recovery

  2018-10-24

  

  Results Discussion Muscle recovery after traumatic injuries such as an occupational crush or blast suffered during military combat canonically induces a predisposition for additional injuries and chronic pain owing to incomplete regeneration of the tissue. Our understanding of how different fa

• br Results br Discussion br Experimental Procedures

  2018-10-24

  

  Results Discussion Experimental Procedures Author Contributions Acknowledgments The authors thank Robbert Zalm for cloning and producing viral particles, Frank den Oudsten for producing glia feeders, Rien Dekker for expert assistance in electron microscopy, and members of the CNCR iPS

• br Results br Discussion Here we present a method to

  2018-10-24

  

  Results Discussion Here, we present a method to induce a pluripotent-like state even in tumor NVP-TNKS656 with a high mutational load. Melanoma cells harboring BRAF or NRAS mutations were amenable to reprogramming similarly to wild-type cells. In contrast to the “classical” reprogramming prot

• Another potential explanation for the lack

  2018-10-24

  

  Another potential explanation for the lack of efficient conversion in our current work could be explained by downregulation of NEUROD1 expression shortly after its overexpression. Indeed, in our current work, staining for NEUROD1 at 10 dpi showed a relative lack of NEUROD1 expression in GFP+ cells.

• Approaches in the literature The literature on sustainabilit

  2018-10-23

  

  Approaches in the literature The literature on sustainability of fiscal policy that applies the temporal government budget constraint started with the seminal article by Hamilton and Flavin (1986) who test whether the budget deficit path follows a stationary stochastic process. The rejection of the

• The paper is organized as follows In Section we

  2018-10-23

  

  The paper is organized as follows. In Section 2 we detail the formulation of the cardinality-constrained minimum variance portfolios and the methodology to evaluate portfolio performance. Section 3 presents the data used in the paper. Section 4 discusses the results of the empirical application. Fin

• br Material and Methods br Results br

  2018-10-23

  

  Material and Methods Results Discussion We document the expression of EBV viral miRNAs by three independent methods, small RNA sequencing, qRT-PCR and miRNA-ISH in malignant B cells, plasma and bone marrow biopsies of patients with CLL. It is noteworthy that more than 90% of adults older th

• MtDNA is usually present in multiple identical copies in

  2018-10-23

  

  MtDNA is usually present in multiple identical copies in the cells, but the location of MtDNA close to the electron transport chain renders it more susceptible to ROS induced damage and mutations. In diabetes patients, MtDNA may be exposed to hyperglycaemia induced oxidative stress (Singh et al., 20

• br Discussion Our studies suggest that over expression of

  2018-10-23

  

  Discussion Our studies suggest that over-expression of both XIST and KDM5C genes may serve as a biological marker for diagnosis of bipolar disorder with mania and psychosis or recurrent major depression in females. In 60 lymphoblastoid cell lines established from randomly collected female patient

• The levels of LRG have been shown to be

  2018-10-23

  

  The levels of LRG1 have been shown to be elevated in the serum and urinary exosomes of lung cancer patients (Li et al., 2011; Liu et al., 2012) with this protein also being identified in lung tumour tissue. The role of LRG1 is not fully understood, although it is of interest due to its role in angio

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