• FIPI Immunohistochemistry in tissue samples showed the expre

  2024-02-18

  

  Immunohistochemistry in tissue samples showed the expression of several nuclear receptor co-activators, including NCOA1, NCOA2, NCOA3, CREBBP, and EP300, in 85–100% of FIPI tumors even some of which lacked AR expression (Boorjian et al., 2009). Knockdown of each co-activator also resulted in signif

• TG101209 Aggregated A species have been studied

  2024-02-18

  

  Aggregated Aβ species have been studied by an array of biophysical techniques, including atomic force microscopy (AFM) [55], transmission electron microscopy (TEM) [56], [57], X-ray diffraction [58], Fourier transform infrared (FTIR) [59], [60], circular dichroism (CD) [61], and nuclear magnetic res

• In conclusion we demonstrated that

  2024-02-18

  

  In conclusion, we demonstrated that, in the skeletal muscle of rats with T1DM, CRBN levels increased and AMPK, Akt, GLUT4, PGC-1α, and FNDC5 levels decreased, resulting in increased fasting glucose levels. Aerobic exercise training decreased levels of CRBN, which was possibly mediated by AMPK, Akt,

• WKY and SHR strains have

  2024-02-18

  

  WKY and SHR strains have important differences mainly in their sympathetic status but also in the activity of the RAS. The development of hypertension in SHR is clearly related to an increase in sympathetic activity [51], [11]. In addition, increased renal sympathetic nerve activity led to an increa

• Initially DPP DPP and prolyl tripeptidyl peptidase A PtpA we

  2024-02-18

  

  Initially, DPP4, DPP7, and prolyl tripeptidyl peptidase A (PtpA) were the only exopeptidases identified in P. gingivalis. These share substrates according to their altered specificities, as DPP4 is highly specific for Pro at the penultimate position from the N-terminus (P1 position), though it accep

• Tumor suppressor ARF regulates the activity of p by inhibiti

  2024-02-10

  

  Tumor suppressor ARF regulates the activity of p53 by inhibiting the functions of Mdm2. ARF is induced by hyperproliferative signals emanating from oncogenic Ras, overexpressed c-myc, and from deregulated E2F . ARF prevents p53 degradation and leads to increased p53 function by sequestering Mdm2 to

• br Concluding Remarks and Future Perspectives Fluorescent an

  2024-02-09

  

  Concluding Remarks and Future Perspectives Fluorescent SB 290157 trifluoroacetate salt have helped researchers to elucidate antibiotic MOA and off-target interactions, to screen for new antibiotics, to detect antibiotics in the environment, to track antibiotic uptake throughout cells and organis

• br Introduction Alzheimer s disease

  2024-02-09

  

  Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different Phosphatase Inhibitor Cocktail 2 (100X in ddH2O) areas, resulting in cognitive impairment and behavioral changes (O'Nei

• br Materials and Methods br Results br Discussion

  2024-02-09

  

  Materials and Methods Results Discussion Voluminous literature is available describing the regulation of orexin receptor antagonist homeostasis by central and peripheral mechanisms in poultry [35,36]. However, the neuroendocrine mechanism(s) of photoperiod induced hypothalamic regulation of

• ADORs accomplish a variety of physiological effects in diffe

  2024-02-09

  

  ADORs accomplish a variety of physiological effects in different tissues. In neurons, ADORs regulate the release of neurotransmitters such as dopamine and glutamate (Ferré et al., 1992; Fredholm and Dunwiddie, 1988; Ginsborg and Hirst, 1972; Gonçalves et al., 2015; Quarta et al., 2004; Stella et al.

• Oxidative stress has recently been reported

  2024-02-09

  

  Oxidative stress has recently been reported as one of the important mechanisms of toxic effect of Cd2+[43]. The mechanism of Cd2+-induced oxidative stress involves an imbalance between generation and removal of ROS in tissues and cellular components, causing damage to membranes, DNA, and proteins [4

• The pathogenesis of d penicillamine induced MG is not clear

  2024-02-09

  

  The pathogenesis of d-penicillamine-induced MG is not clear. The repertoire of anti-AChR tetrandrine in d-penicillamine-induced MG has been shown to be similar to that in idiopathic MG in terms of AChR antigenic regions, suggesting a common immune mechanism (Tzartos et al., 1988). About 20% of d-pe

• The zebrafish Danio rerio is a popular model organism for

  2024-02-09

  

  The zebrafish (Danio rerio) is a popular model organism for virtually any biological function of vertebrates, and has, therefore, received a wide distribution in particular in developmental biology and toxicology (Strähle et al., 2012). With respect to AChE, the zebrafish has, e.g., been identified

• The nAChR has been considered an interesting

  2024-02-09

  

  The α7 nAChR has been considered an interesting potential target for numerous therapeutic indications over the last two decades, with GTS-21 one of the first candidates proposed for Alzheimer's disease [2], [3], [23]. Unfortunately, although many α7-selective agonists have been developed [21], none

• br Materials and methods br Results br

  2024-02-09

  

  Materials and methods Results Discussion The data presented here demonstrate the important role of B lymphocyte-expressed α7 nAChRs in regulating the antibody immune response. It is shown that, in addition to ACh produced by activated T lymphocytes (Fujii et al., 2012), activated B lymphocy

16090 records 193/1073 page Previous Next First page 上5页 191192193194195 下5页 Last page