• br Conflict of interest br Acknowledgments This work

  2023-10-30

  

  Conflict of interest Acknowledgments This work was supported by research grant [PR26/20326] from Santander Bank/UCM. The authors would like to thank Miguel Capo, Professor of Toxicology from the Universidad Complutense de Madrid, for his counseling during the preparation of the present work.

• br Material and methods br

  2023-10-30

  

  Material and methods Results Discussion Clinical gene therapy trials with viral vectors have been in use for treatment of various genetic disorders and diseases, however efficacious, targetable and highly reliable non-viral delivery systems are needed for safe and long-term applications. De

• br Discussion In our current study

  2023-10-30

  

  Discussion In our current study, we demonstrated that both the metastatic and recurrent ovarian cancer tissues expressed lower levels of p62 when compared with the patient-matched primary tumor samples. High 3065 sale levels of p62 were associated with long progression-free survival of patients

• Pompe disease is accompanied by the deficiency of the lysoso

  2023-10-30

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the Loratadine unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation results in the s

• Oocytes from the African clawed frog Xenopus laevis

  2023-10-30

  

  Oocytes from the African clawed frog Xenopus laevis have been widely used as an expression system to study the modulation of NMDA receptors by metabotropic receptors, such as metabotropic glutamate receptors [12], μ opioid receptors [13], insulin receptors [14] and serotonin receptors [15]. No data

• Functional enhancers are often composed of binding motifs of

  2023-10-30

  

  Functional enhancers are often composed of binding motifs of multiple key transcription factors to confer spatial and temporal regulation of genes in a certain context. In the uterus, the difference between the number of genes that have associated PGR occupancy and that of progesterone responsive ge

• Optical coherence tomography angiography is another promisin

  2023-10-27

  

  Optical coherence tomography angiography is another promising method for the assessment of corneal neovascularization. This relatively new modality is not yet widely used in part because of current limitations in the definition of images produced, lack of functional information, and inability to det

• br Acknowledgments br Introduction Amyloid deposit formation

  2023-10-27

  

  Acknowledgments Introduction Amyloid deposit formation is defined by the aggregation of β-sheeted forms of proteins that appear as starch-like amorphous material [1], [2]. Using a Kongo red stain, amyloids show birefringence behavior and an apple-green to reddish multicolor emission. Extracere

• br Experimental Procedures br Acknowledgments br Introductio

  2023-10-27

  

  Experimental Procedures Acknowledgments Introduction Cellular and molecular mechanisms underlying synaptic plasticity in the deoxythymidine receptor are thought to be involved in memory acquisition. Synaptic plasticity is categorised into two main types, long-term depression (LTD) and long

• Dose Response Studies Against Puromycin Sensitive Aminopepti

  2023-10-27

  

  Dose–Response Studies Against Puromycin–Sensitive Aminopeptidase (PSA). PSA is a ubiquitous metallopeptidase encoded by the NPEPPS gene with subcellular distribution in the cytosol and nucleus [49]. Comprising of a 919 amino Azaserine sale sequence, it has a broad substrate specificity, and is resp

• br Available treatment modalities for individuals with NAFLD

  2023-10-27

  

  Available treatment modalities for individuals with NAFLD There are several treatment modalities currently used or in clinical trials for individuals with NAFLD. The most widely recommended treatment is a lifestyle modification plan. As little as 5% weight loss has been shown to improve NASH hist

• Asparagine synthetase ASNS is a glutamine

  2023-10-27

  

  Asparagine synthetase (ASNS) is a glutamine amidotransferase that catalyzes ATP-dependent synthesis of asparagine and glutamate from aspartate and glutamine. Upregulation of ASNS expression renders leukemia cells resistant to l-asparaginase treatment, and ASNS is essential for cell survival in the a

• The application of diuretics induce

  2023-10-27

  

  The application of diuretics induce an increased rate of water exiting brain cells encouraging the formation of increased intracellular polyphosphoric acid. In the absence of the diuretic water is retained in cells converting polyphosphoric tepp to monophosphoric acid. The latter change decreases t

• In this study using pure enzyme preparations

  2023-10-27

  

  In this study, using pure enzyme preparations of human placental recombinant AR (hAR) and of AR isolated from bovine lens (bAR), which behave as Michaelis 624 mg with glyceraldehyde as substrate, is shown that an apparent negative cooperativity action for glucose still occurs. We present evidence f

• Application of the broad acting HTR

  2023-10-27

  

  Application of the broad-acting 5-HTR antagonist methiothepin (Bard et al., 1996, Hoyer et al., 1994, Peroutka, 1990) converted the TBS-induced response of both thalamocortical and intracortical A1 synapses from LTP to LTD, an effect that was mimicked by the selective 5-HT2R antagonist ketanserin (L

16042 records 251/1070 page Previous Next First page 上5页 251252253254255 下5页 Last page