• Another option is to use the thiol groups of cysteine

  2021-07-26

  

  Another option is to use the thiol groups of cysteine residues, which can be modified by use of PEG-maleimide and vinyl sulfone. However, changes in PEGylation interactions or reaction conditions can result in changes in the functional properties of the therapeutic proteins [[50], [51], [52]]. A st

• br Making the BN Cox model computationally efficient

  2021-07-26

  

  Making the BN-Cox model computationally efficient One of the challenges to applying the BN-Cox model is an exponential growth of the conditional probability tables (CPT) corresponding to the survival variables, as the number of risk factors increases [22]. When the number of risk factors is high,

• br Discussion The present study found cholinesterase activit

  2021-07-26

  

  Discussion The present study found cholinesterase activity in Saccostrea sp. to vary significantly among three tissue types (digestive gland, gills, adductor muscle) and to respond differentially to four toxicants, three of which were non-organophosphates. Furthermore, a comparison of enzyme acti

• The contradictory effects exerted by metals

  2021-07-26

  

  The contradictory effects exerted by metals were reviewed by Nunes (2011) that stated that the concentration and the species of metal can cause specific effects in ChE activity. Being environmentally exposed, the organism can accumulate metals in tissues, increasing their concentrations. Some author

• Our published results also show that the Y and

  2021-07-26

  

  Our published results also show that the Y2 and the Y5, but not the Y1, receptors mediate NPY-induced excitation-secretion coupling in EECs (Abdel-Samad et al., 2012). Thus, it is highly important to consider controlling ET-1 circulating level via blockade of Y2 and/or Y5 receptor activation (Abdel-

• A large fraction of UCEs

  2021-07-26

  

  A large fraction of UCEs are transcribed (T-UCEs) in a tissue specific manner, and are deregulated in several human cancers (Calin et al., 2007, Fabbri et al., 2008, Fassan et al., 2014, Olivieri et al., 2016). Indeed, it has been shown that T-UCEs may also act as long non-coding RNAs (lncRNAs) regu

• br Role of ERK signaling in preventive and

  2021-07-26

  

  Role of ERK signaling in preventive and therapeutic potential of flavonoids in neurodegenerative diseases ERK is one of the main pharmacological targets of natural phenolic compounds and contributes to several therapeutic approaches including anti-atherogenic, anti-cancer, anti-colitis, anti-arth

• In principle in vitro techniques for assessing enzyme

  2021-07-26

  

  In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized Proteinase K receptor lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recom

• Contrary to the downregulation of S PR

  2021-07-26

  

  Contrary to the downregulation of S1PR family GPCRs, CLL cells have increased mRNA expression of the lysophosphatidic Anti-cancer Compound Library sale (LPA) family receptors LPAR1, LPAR3 and LPAR4 compared to normal B cells [47]. Increased LPAR1 mRNA has been shown to be associated with more aggres

• br Materials and methods br Results br Discussion Our

  2021-07-26

  

  Materials and methods Results Discussion Our results based on the Y2H analysis between the U-box-motif region of E3s and the UBC domain of E2s showed that, among 40 rice E2s, 11 E2s accounted for 70% of the interactions with 17 ARM-U-box E3 Ub-ligases (Fig. 2, Fig. 3). These 11 E2s belong t

• br Expression of DNMTs during

  2021-07-26

  

  Expression of DNMTs during testicular development In most multicellular organisms, male and female germ cells are the origin of development of an organism, and they provide inheritance of genetic and epigenetic information across the generations. Primordial germ cells (PGCs) derive from a subset

• Recent studies from the literature

  2021-07-26

  

  Recent studies from the literature have identified new cetp inhibitors of antiviral agents able to target diverse host factors indispensable for efficient virus replication: as an example, the human DEAD-box polypeptide 3 (DDX3) inhibitor, 1-[4-(4-methyl-1H-1,2,3-triazol-1-yl)phenyl]-3-o-tolylurea

• br Materials and methods br Results br Discussion Although n

  2021-07-26

  

  Materials and methods Results Discussion Although no increase in DAPK activity was detected at early time points associated with neuronal apoptosis, it is possible that the spread of apoptosis through the LY2109761 following HI is not synchronized enough to yield a large, consistent fluctu

• The genomic DNA sequences of CXCL and

  2021-07-26

  

  The genomic DNA sequences of CXCL8 and CXCRs were retrieved from the fugu genome database v4.0. The intron–exon boundaries were identified with the corresponding cDNA sequences. This comparison revealed that the fugu gene is about 1.13kb long and contains four exons separated by three introns (top

• In the present study we investigated the

  2021-07-23

  

  In the present study we investigated the effect of morphine withdrawal on G-protein coupling to opioid and ET receptors in neonatal rats. Morphine-induced G-protein activation was significantly higher in neonatal rats undergoing morphine withdrawal; suggesting enhanced coupling of the receptors to G

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