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CaMKII phosphorylation of L type Ca channels alters channel
2019-06-25
CaMKII phosphorylation of L-type Ca2+channels alters channel gating by increasing open probability. CaMKII increases the window current of ICa-L, increasing the probability of the channels reopening during phase 2 4μ8C molecular and predisposing to early afterdepolarizations. Recently identified pho
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In patients with surgically corrected CHD
2019-06-25
In patients with surgically corrected CHD, the anatomic position of the atriotomy scar as the arrhythmogenic substrate is commonly found in the free wall and not in the septum [8]. The cause of this large area of low voltage (“atrial myopathy”) is unclear. Possible explanations include interruption
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The effects of zoledronic acid
2019-06-25
The effects of zoledronic p2x7 are most likely due to impairment of the tumour-driven alterations to the bone microenvironment. This may render the bone marrow cavity unfavourable for metastatic growth, potentially redirecting tumour cells to other sites, including the periosteal surface. Whereas co
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br Los dos libros que a continuaci n
2019-06-25
Los dos libros que Bardoxolone methyl continuación se reseñan solo en parte coinciden en su objeto de estudio y el método de tratarlo. El libro de Hugo J. Verani ofrece una minuciosa interpretación de la poética de Octavio Paz, especialmente de la que domina en sus poemas extensos. También Evodio
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br Planteamientos Previos El presente estudio muestra la est
2019-06-25
Planteamientos Previos El presente estudio muestra la estrecha relación entre los procesos identitarios y las transformaciones de los contextos migratorios. Centrándose en el caso de los migrantes indígenas de Otavalo (Ecuador) en una de las ciudades del sur de España, la investigación parte de u
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Estes n meros d o um ind
2019-06-25
Estes números dão um indício do clima de insegurança, e muitas vezes de terror, que pairou sobre o país no período. Este ambiente foi explorado em diversos sentidos pelo regime fujimorista. De um lado, atribuiu para si o mérito de ter desarticulado MLN120B what insurgência e pacificado o país, o que
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Si bien existen otras bases de datos similares
2019-06-25
Si bien existen otras bases de datos similares como Scielo y Dialnet, desde las cuales también se podría haber recuperado la documentación pertinente para este estudio, se estimó que redalyc representaba más adecuadamente el mapeo de la región, debido NP118809 structure que Scielo tiene un sesgo mar
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Virulence genes were investigated among all beta lactamase
2019-06-25
Virulence Fenofibrate were investigated among all beta-lactamase-producing isolates using PCR. There were 54% (n=54) isolates that had one or more than one type of all these six virulence factors. Among all the isolates, 40.74% (n=22) produced OprI (249 bp in size) and 29.62% (n=16) expressed OprL
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br Al hablar del requisito sine qua non de
2019-06-24
Al hablar del requisito sine qua non de conocer la lengua uitoto, vale la pena hacer un paréntesis para repasar el estado de los estudios propiamente lingüísticos. Diferentes recuentos bibliográficos sobre las fuentes para el estudio de las lenguas de la Amazonia colombo-peruana, reportan que los
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Ante estas opiniones hay que tomar
2019-06-24
Ante estas opiniones, hay que tomar en cuenta que: “investigaciones recientes muestran que los pueblos indígenas han emergido junto hordenine dissolve solubility procesos de revitalización étnica y cultural, que han transformado el escenario sociopolítico y han puesto en tela de juicio las antiguas
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br Discussion Our results confirm that germline
2019-06-24
Discussion Our results confirm that germline variations in the TPMT gene are associated with treatment outcome in children with ALL [5]. The ability of TPMT to catalyze S-methylation and inactivate 6-mercaptopurine makes it a major determinant of 6-mercaptopurine toxicity. Furthermore, reduced TP
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The recently published global consensus recommendations on p
2019-06-24
The recently published global consensus recommendations on prevention and management of rickets advocate for the eradication of rickets and osteomalacia through implementation of national supplementation and food fortification programmes containing vitamin D, calcium, or both. On the basis of high-q
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However during pacing at the most proximal CS
2019-06-24
However, during pacing at the most proximal CS electrodes (CS 9–10), although the conduction time to the CS 1–2 was prolonged, the septal to lateral activation sequence (CS 5–6 to CS 3–4 to CS 1–2) indicated the presence of residual conduction on the MI line (Fig. 3B). Detailed mapping on the MI lin
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Some patients developed osmotic demyelination
2019-06-24
Some patients developed osmotic demyelination disease (ODS) after rapid correction of hyponatremia. Predisposing factors to development of ODS were syndrome of inappropriate antidiuretic hormone, alcoholism, liver cirrhosis, liver transplantation, renal failure, burns, malnutrition, or neoplasm. Oth
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Bisphosphonates are a well established standard of care
2019-06-24
Bisphosphonates are a well-established, standard-of care treatment option to reduce the frequency and severity and time of onset of the skeletal related events (SREs) in patients with bone metastases due to either solid tumours or multiple myeloma [21–33]. From many years, BPs have been incorporated
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