• The electrophysiological mechanisms underlying high frequenc

  2019-06-14

  

  The electrophysiological mechanisms underlying high frequency activity observed in the PLA during SRAF could be reentry (rotor) or focal discharges (triggered activity). To discriminate between these mechanisms, we perfused ryanodine (10–40μM) or caffeine (5mM) to abolish calcium overload-mediated t

• br The west African outbreak of Ebola virus disease

  2019-06-14

  

  The 2014–15 west African outbreak of Ebola virus disease is unprecedented in scale, especially in Sierra Leone, which as of May 15, 2015, had reported 8598 confirmed cases and 3538 confirmed Ebola-related deaths. Sierra Leone\'s response to this emergency has been compromised by a fragile health s

• En este proceso de integraci

  2019-06-14

  

  En este proceso de integración y unidad latinoamericana y caribeña, la imagen política y diplomática de Estados Unidos se vio seriamente mermada por su terrible campaña contra el terrorismo. Su economía se mantiene sumergida en una aguda crisis financiera desde 2008, la más profunda desde 1929. A pe

• glucocorticoid receptor br Introduction Acute myeloid leukem

  2019-06-14

  

  Introduction Acute myeloid leukemia (AML) remains a hematologic malignancy with poor outcome and a high risk for relapse believed to be caused by the survival of leukemic stem cells (LSCs), which are responsible for disease repopulation following treatment [1]. This important implication of LSCs

• br The Editorial in about global

  2019-06-13

  

  The Editorial in about global health inequity raises some important issues. The global health Z-YVAD-FMK long ago acknowledged the worldwide disparities in health, but it has failed to take action; most of the efforts have been made in reporting the disparities among specific population groups.

• After a decade of political and economic crisis between

  2019-06-13

  

  After a decade of political and economic crisis between 1999 and 2010, health education in Zimbabwe was in a desperate state and required a major overhaul. UZCHS reported a 60% decrease in medical student enrolment, a 61% faculty vacancy rate, a 50% increase in failure rate, and the specialist train

• STI571 Recently denosumab demonstrated a significant

  2019-06-13

  

  Recently, denosumab demonstrated a significant delay in the onset of detectable bone lesions in men with castration resistant prostate cancer compared to placebo . This could indicate some kind of efficacy of the compound as anticancer agent and consequently an indirect confirmation of the role of R

• The standard therapy for chordoma is excision

  2019-06-13

  

  The standard therapy for chordoma is excision. Local recurrence, but not metastasis, is a major determinant of prognosis. Because local recurrence is related to initial surgical margin and intra-operative tumor cell contamination, achieving a safe margin is very important. Boriani [6] reported 153

• Human ether a go go related

  2019-06-13

  

  Human-ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly-activating delayed-rectifier potassium protein kinase inhibitor that generate IKr. This outward potassium current is elicited during the plateau phase of action potentials and is required for repolarization [4]. After being tr

• For the pocket a cm incision was made along

  2019-06-13

  

  For the pocket, a 6cm incision was made along the predefined Langer’s lines. Subcutaneous dissection was carried out using an electrosurgical cutting and coagulation device, parallel to the incision, down to the fascia overlying the latissimus dorsi muscle (shining transparent membrane). Intermuscu

• However as the above results included patients who

  2019-06-13

  

  However, as the above results included patients who underwent RMN ablation during its introduction to our center when physicians were still in the process of familiarization, we proceeded to compare fluoroscopy and procedural times in the most recent 50 patients undergoing ablation in each cohort. T

• br Introduction Aplastic anemia AA is a

  2019-06-13

  

  Introduction Aplastic anemia (AA) is a rare disease characterized by pancytopenia and a hypocellular bone marrow. Specific cytogenetic abnormalities, monosomy 7 and trisomy 8, are frequently associated with clonal evolution [1]. Clonal cytogenetic abnormalities also may be present with hypocellul

• Based on our subgrouping according

  2019-06-12

  

  Based on our subgrouping according to ECG patterns, men were predominant in the Br, ER, or Br–ER group compared with the true IVF group (Table 1). This sex difference was also noted in previous reports [15–17] and may be partially due to different levels of Ito channel expression between sexes [18].

• OSA is a risk factor for hypertension and

  2019-06-12

  

  OSA is a risk factor for hypertension and stroke in particular [6,7]. Continuous positive airway pressure (CPAP) treatment reduces deaths and cardiovascular events, and improves hypertension control [8,9]. The role of CPAP therapy on the treatment of cardiac arrhythmia is still limited. Here, we rep

• br Introduction Despite the widespread use of bone

  2019-06-12

  

  Introduction Despite the widespread use of bone-targeted agents in the care of patients with bone metastases from prostate and breast cancer, questions regarding the optimal; choice of agent, dose, dosing frequency, and duration of therapy remain unanswered [1–6]. Our research group is interested

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