A 83-01: Precision Modulation of TGF-β Signaling for Orga...

2025-09-28

Explore how A 83-01, a selective ALK-5 inhibitor, enables advanced control over TGF-β signaling pathways to enhance organoid cellular diversity and translational disease modeling. This article provides a unique, in-depth perspective beyond pharmacokinetics, focusing on EMT, cancer, fibrosis, and organoid system innovation.

5-(N,N-dimethyl)-Amiloride: A Next-Gen NHE1 Inhibitor for...

2025-09-27

Discover how 5-(N,N-dimethyl)-Amiloride hydrochloride, a potent Na+/H+ exchanger inhibitor, advances intracellular pH regulation and ischemia-reperfusion injury protection. This in-depth analysis explores its unique mechanisms and broad research applications.

2025-09-26

Discover how EZ Cap Cy5 Firefly Luciferase mRNA (5-moUTP) revolutionizes mRNA delivery and in vivo bioluminescence imaging with advanced 5-moUTP modifications and Cy5 labeling. Gain unique insights into its dual-mode detection and translational efficiency—going beyond existing literature.

Sulfo-NHS-Biotin: Advanced Approaches in Selective Protei...

2025-09-25

Explore the scientific mechanisms and cutting-edge applications of Sulfo-NHS-Biotin, a water-soluble biotinylation reagent for precise cell surface protein labeling. This in-depth guide reveals how Sulfo-NHS-Biotin enables next-generation analyses from affinity chromatography to single-cell secretion profiling.

Sulfo-NHS-SS-Biotin: Precision Tools for Cleavable Cell S...

2025-09-24

Discover how Sulfo-NHS-SS-Biotin, a leading amine-reactive biotinylation reagent, enables precise, reversible cell surface protein labeling. This article uniquely explores its mechanistic advantages, integration with autophagy research, and strategic differentiation from existing protocols.

Protease Inhibitor Cocktail EDTA-Free: Ensuring Proteome ...

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Explore the scientific rationale for using Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) in advanced protein extraction workflows, especially those requiring preservation of phosphorylation and RNA modifications. This article details how this protein extraction protease inhibitor supports rigorous post-translational and post-transcriptional research.

Biotin-16-UTP in Functional lncRNA Interactome Mapping

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Explore how Biotin-16-UTP enables high-specificity biotin-labeled RNA synthesis for dissecting lncRNA-protein interactions and localization, with practical insights into its use in hepatocellular carcinoma research.

ABT-199 (Venetoclax): Illuminating Bcl-2-Dependent Apopto...

2025-09-19

Explore how ABT-199 (Venetoclax), a potent Bcl-2 selective inhibitor, advances the mechanistic study of mitochondrial apoptosis in hematologic malignancies. This article highlights new research intersecting selective Bcl-2 inhibition and nuclear-mitochondrial apoptotic signaling for translational and basic inquiry.

DMXAA (Vadimezan): Advancing Tumor Vasculature Disruption...

2025-09-18

Explore the multifaceted actions of DMXAA (Vadimezan, AS-1404) as a vascular disrupting agent for cancer research. This article delves into its role as a DT-diaphorase inhibitor, apoptosis inducer in tumor endothelial cells, and its emerging relevance to tumor immunity and vasculature normalization.

It was previously demonstrated that dissociation

2025-04-21

It was previously demonstrated that dissociation of the V-ATPase in response to glucose depletion in yeast requires an intact microtubular network [28] and a catalytically active enzyme [29]. Interestingly, mutations in the non-homologous region of the catalytic subunit A are able to block dissociat

The main function of ATR CHK

2025-04-17

The main function of ATR/CHK1 signaling is activating HotStart™ 2X Green qPCR Master Mix checkpoint arrest for S and G2 phases in mammalian cells. There are three checkpoints in response to DNA damage: G1/S, G2/M, and S-phase. The G2/M checkpoint can prevent cells that incur DNA damage in G2 phase

br Acknowledgements We would like to thank Dr

2025-04-16

Acknowledgements We would like to thank Dr. Thomas Blanpied, Sai Sachin Divakaruni, Dr. Helmut Kessels, Feline Lindhout, Dieudonnée van de Willige, and all members of the MacGillavry lab for discussions and critical reading of the manuscript. This work was supported by NWO (ALW-VENI 863.13.020, A

br Regulatory mechanisms of ASK

2025-04-15

Regulatory mechanisms of ASK1 activity The functions of ASK1 in disease ASK1 inhibitor As mentioned above, ASK1 plays a pivotal role in the pathogenesis of various diseases; hence, an ASK1 inhibitor has therapeutic potential. Although inhibitors of the ASK1 downstream kinases p38 and JNK ar

br Discussion br Acknowledgments Writing of

2025-04-15

Discussion Acknowledgments Writing of this review and collection of data from our laboratories that are presented were supported by a grant from the Belgian Science Policy (BELSPO) SSTC Interuniversity Attraction Poles Plastoscine P7/17 to AVDL and JB, multiple grants from the Fund for Scienti

Molecular docking quantitative structure activity relationsh

2025-04-14

Molecular docking, quantitative structure–activity relationship (QSAR) and high-throughput virtual screening (HTVS) studies have a very widespread use in computer-assisted drug design.25, 26, 27, 28 Suvannang et al. used the published X-ray crystallographic data to examine known aromatase inhibitors